The 16 young people set off from The Royal Manchester Children’s Hospital and cycled to Alder Hey in Liverpool along the Liverpool-East Lancashire Road.
They hope to raise £500 for an RAF appeal that will see presents delivered to the wards this Christmas.
“We were looking for ways to raise the money and thought this was a good way to involve both the hospitals,” said Amy Davies, a former pupil at Wade Deacon High School.
All those taking part are on the Public Services BTEC course at Priestley College and will be hoping to match last year’s total of £1,500 when their fundraising efforts are completed.
They have until December to hit their target when they hand over the money to the RAF who will then buy the presents for the poorly children.
Priestley students will then wrap hundreds of presents before an RAF helicopter carrying Father Christmas lands at the college to collect the gifts and deliver them to the hospitals.
“We saw what the students did last year and found that very inspiring so we are hoping to do as well – if not better – this year,” said Lauren Jones, a former pupil of The Heath.