The team of AS Level learners at Priestley College raised nearly £100 for Alder Hey after selling cake pops and sweets to fellow students and tutors.
Former Tower College pupil Megan Gilbert, from Chapelford, baked the cakes after the team agreed that would be the best way to make a profit.
“We all put in £1.50 to start off the business and were given the option of having that back, but no one did because we wanted it to go to Alder Hey,” she said.
Gabriella Sharp, who is from Thelwall and formerly attended Cardinal Newman, said the challenge had tested the students’ organisational skills.
They had to ensure their stall was manned and work that around each others’ timetables.
“People did just give us random donations because they didn’t want a cake, which really helped,” she said.
In 2015 Alder Hey will open a purpose-built hospital in the park next door to its current site.
The hospital treats everything from common illnesses to highly complex and specialist conditions.